4-Fluorobenzoyl chloride → HCID 86592047, compound

HRID 1349560Notes

Reaction equation

C(N)(=O)CC.[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]([C@H:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([O:28][CH3:29])[CH:26]=3)[N:21]([C:30]([C:32]3[O:33][CH:34]=[CH:35][CH:36]=3)=[O:31])[C@@H:20]([C:37]([F:40])([F:39])[F:38])[CH2:19]2)[C:14](=[O:17])[CH2:15][CH3:16])=[CH:9][CH:8]=1.ClC1C=CC(N([C@H]2C3C(=CC=C(OC)C=3)N(C(=O)C3C=CC(F)=CC=3)[C@@H](C(F)(F)F)C2)C(=O)CC)=CC=1.FC1C=CC(C(Cl)=O)=CC=1>>[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]([C@H:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([O:28][CH3:29])[CH:26]=3)[N:21]([C:30]([C:32]3[O:33][CH:34]=[CH:35][CH:36]=3)=[O:31])[C@@H:20]([C:37]([F:39])([F:38])[F:40])[CH2:19]2)[C:14](=[O:17])[CH2:15][CH3:16])=[CH:9][CH:8]=1

Participants

Reactant 3

HCID 678794-Fluorobenzoyl chloride

HCID 86592048HCID 86592048, compound

HCID 86592049HCID 86592049, compound

Product 1

HCID 86592047HCID 86592047, compound

Procedure

(±)-Cis-N-(4-chloro-phenyl)-N-[1-(furan-2-carbonyl)-6-methoxy-2-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-4-yl]-propionamide propionamide was made following the procedure for the synthesis of (±)-cis-N-(4-chloro-phenyl)-N-[1-(4-fluoro-benzoyl)-6-methoxy-2-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-4-yl]-propionamide, substituting 2-furoyl chloride chloride for 4-fluorobenzoyl chloride.

Sources & evidence

ORD record: ord-a58aea0d7df74adabf43eb0ccd2c551b
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07211672B2

Reaction notes

Loading…