Hydrazine → HCID 22479971, compound

HRID 1349582Notes

Reaction equation

HRID 1349582 reaction equation
F[C:2]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[NH2:20][NH2:21]>>[C:6]1([C:4]2[C:3]3[C:2](=[CH:15][CH:14]=[C:13]([C:16]([F:19])([F:18])[F:17])[CH:12]=3)[NH:21][N:20]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 5702552-Fluoro-5-(trifluoromethyl)benzophenone

Product 1

HCID 22479971HCID 22479971, compoundYield 76%

Procedure

A solution of 2-fluoro-5-trifluoromethylbenzophenone (0.828 g, 3.09 mmol) in hydrazine was heated at 130° C. for 3 hours. The reaction mixture stood at ambient temperature overnight and gave white needles. It was filtered and washed with hexane to provide the title compound (0.617 g, 76% yield): mp 152° C.; 1H NMR (CDCl3) δ 10.63 (br s, 1H), 8.33 (s, 1H), 7.96 (d, 2H), 7.48–7.67 (m, 5H); EI-MS (m/z) 262 [M]+.

Workup

  1. customgave white needles
  2. filtrationIt was filtered
  3. washwashed with hexane

Sources & evidence

ORD record
ord-a85e046ce38f442e9ca39fa1f82f6b22
Source dataset
uspto-grants-2007_05
Patent number
US07211594B2

Reaction notes

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