Hydrazine → HCID 12587996, compound

HRID 1349829Notes

Reaction equation

HRID 1349829 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][C:8]([O:10]C)=O.[NH2:12][NH2:13]>C(O)C>[NH2:12][NH:13][C:8](=[O:10])[CH2:7][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][NH:1]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 5214606Methyl piperidin-2-ylacetate

Product 1

HCID 12587996HCID 12587996, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of methyl 2-piperidylacetate (1.082 mL, 5.84 mmol) in 1 mL of anhydrous ethanol was added anhydrous hydrazine (0.283 mL, 5.84 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as a gummy white solid in a quantitative yield and was used without further purification: ES-MS (m/z) 158 [M+H]+.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature overnight
  3. customThe solvent was then removed under reduced pressure
  4. customthe product was isolated as a gummy white solid in a quantitative yield
  5. customwas used without further purification

Sources & evidence

ORD record
ord-09de2ff3a0c7420283761a3ceb3826b7
Source dataset
uspto-grants-2007_05
Patent number
US07211594B2

Reaction notes

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