HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → Dimethylformamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 22480305 | HCID 22480305 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Dimethylformamide | HCID 6228 | 536.1% |
| Product | HCID 131726357 | HCID 131726357 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 367 A using the following amounts of reagents: 3-(5-cyano-1-perhydro-2H-pyran-2-yl-1H-indazol-3-yl)benzoic acid (2.65 g, 7.63 mmol), 4-fluoroaniline (2.20 mL, 23.22 mmol), HOBT (3.1 g, 22.95 mmol), EDAC.HCl (4.4 g, 22.95 mmol), anhydrous THF (50.0 mL) and anhydrous DMF (15.0 mL) (2.99 g, 89% yield) as a yellow solid. ES-MS (m/z) 441 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211594B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-26142eddc52c4841a3d033d24ac5ca6f |
| Source note | uspto-grants-2007_05 |