2-Amino-6-fluorobenzylamine → HCID 178432155, compound

HRID 1349946Notes

Reaction equation

HRID 1349946 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][NH2:5].[CH2:11](C(CC)(CC)C([O-])([O-])[O-])[CH3:12]>C(O)C>[F:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]2[C:3]=1[CH2:4][NH:5][C:11]([CH3:12])=[N:1]2

Participants

4

Reactant 2

HCID 5789982-Amino-6-fluorobenzylamineHCID 21875354Triethylorthoaceate

Product 1

HCID 178432155HCID 178432155, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-amino-6-fluorobenzylamine (1.1 g, 7.86 mmol) and triethylorthoacetate (1.58 mL, 8.64 mmol) in ethanol (30 mL) was heated at 80° C. for 14 h. The reaction mixture was allowed to cool to room temperature and evaporated in vacuo. The yellow oil was triturated with diethyl ether to give the title compound as white solid (0.74 g, 57%).

Workup

  1. customevaporated in vacuo
  2. customThe yellow oil was triturated with diethyl ether

Sources & evidence

ORD record
ord-f52556c8a9184fad8c10bd7d68a18e94
Source dataset
uspto-grants-2007_05
Patent number
US07214674B2

Reaction notes

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