5-(2-(Methanesulfonyloxy)ethoxy)-2-methylquinazoline → 8-{1-[2-(2-Methylquinazolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one

HRID 1349963Notes

Reaction equation

HRID 1349963 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]2[C:17]3[O:16][CH2:15][C:14](=[O:18])[NH:13][C:12]=3[CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.CS(O[CH2:24][CH2:25][O:26][C:27]1[CH:36]=[CH:35][CH:34]=[C:33]2[C:28]=1[CH:29]=[N:30][C:31]([CH3:37])=[N:32]2)(=O)=O>>[CH3:37][C:31]1[N:30]=[CH:29][C:28]2[C:33](=[CH:34][CH:35]=[CH:36][C:27]=2[O:26][CH2:25][CH2:24][N:1]2[CH2:6][CH2:5][CH:4]([CH2:7][C:8]3[C:17]4[O:16][CH2:15][C:14](=[O:18])[NH:13][C:12]=4[CH:11]=[CH:10][CH:9]=3)[CH2:3][CH2:2]2)[N:32]=1

Participants

3

Reactant 2

HCID 179651395-(2-(Methanesulfonyloxy)ethoxy)-2-methylquinazolineHCID 210937508-piperidin-4-ylmethyl-4H-benzo[1,4]oxazin-3-one

Product 1

HCID 210937438-{1-[2-(2-Methylquinazolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one

Procedure

The title compound was prepared from 8-(piperidin-4-ylmethyl)-4H-benzo[1,4]oxazin-3-one and 5-(2-(methanesulphonyloxy)ethoxy)-2-methylquinazoline in a similar manner to Example 1.

Sources & evidence

ORD record
ord-dd6766a73fca49b68970f687003177f0
Source dataset
uspto-grants-2007_05
Patent number
US07214674B2

Reaction notes

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