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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1349964Generated: October 30, 2026

5-(2-Bromoethoxy)-2-methylquinoline → 4-Methyl-8-{1-[2-(2-methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one

https://huagongshe.com/reaction/1349964

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(2-Bromoethoxy)-2-methylquinolineHCID 11737192—
Reactant4-methyl-8-(piperidin-4-ylmethyl)4H-benzo[1,4]oxazin-3-oneHCID 21093745—
Product4-Methyl-8-{1-[2-(2-methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-oneHCID 10310420—

Reaction Steps

The title compound was prepared from 4-methyl-8-(piperidin-4-ylmethyl)4H-benzo[1,4]oxazin-3-one and 5-(2-bromoethoxy)-2-methylquinoline in a similar manner to Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07214674B2
Source datasetuspto-grants-2007_05
ORD IDord-b5d90462d81d4fa1b1bec110a392345b
Source noteuspto-grants-2007_05