5-(2-(Methanesulfonyloxy)ethoxy)-2-methylquinazoline → 4-Methyl-8-{1-[2-(2-methylquinazolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one
Reaction equation
[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH2:12][CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[C:6]=2[O:5][CH2:4][C:3]1=[O:19].CS(O[CH2:25][CH2:26][O:27][C:28]1[CH:37]=[CH:36][CH:35]=[C:34]2[C:29]=1[CH:30]=[N:31][C:32]([CH3:38])=[N:33]2)(=O)=O>>[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH2:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:25][CH2:26][O:27][C:28]4[CH:37]=[CH:36][CH:35]=[C:34]5[C:29]=4[CH:30]=[N:31][C:32]([CH3:38])=[N:33]5)[CH2:15][CH2:14]3)[C:6]=2[O:5][CH2:4][C:3]1=[O:19]Participants
3
Procedure
The title compound was prepared from 4-methyl-8-(piperidin-4-ylmethyl)-4H-benzo[1,4]oxazin-3-one and 5-(2-(methanesulphonyloxy)ethoxy)-2-methylquinazoline in a similar manner to Example 1.
Sources & evidence
- ORD record
- ord-42f00ed059ed4bd1a705fb18d19f89c6
- Source dataset
- uspto-grants-2007_05
- Patent number
- US07214674B2
Reaction notes
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