Thionyl Chloride → HCID 21093904, compound

HRID 1350048Notes

Reaction equation

HRID 1350048 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]2[C:16](=[O:17])[NH:15][C:14](=[O:18])[CH:13]=[N:12]2)=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]2[C:16](=[O:17])[NH:15][C:14](=[O:18])[CH:13]=[N:12]2)=[CH:7][C:3]=1[C:4]([Cl:21])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 11579867HCID 11579867, compound

Product 1

HCID 21093904HCID 21093904, compound

Procedure

A mixture of 2-chloro-5-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-benzoic acid (50 mg) in thionyl chloride (1 ml) was stirred at reflux for 1 hour. The mixture was concentrated under vacuum to provide 50 mg of the title intermediate as an amorphous amber solid that was used immediately in the next step.

Workup

  1. temperatureat reflux for 1 hour
  2. concentrationThe mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-a962d3f97a0c478ca70c57e7343f4406
Source dataset
uspto-grants-2007_05
Patent number
US07214677B2

Reaction notes

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