Hydrochloric Acid → (6-Methoxy-4-isoquinolinyl)methanol hydrochloride

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Reaction Steps

The compound obtained in Step A (0.395 g; 0.0015 mol), in the form of a base, is dissolved in 200 ml of ether. Lithium aluminium hydride (0.14 g; 0.004 mol) is then progressively added while cooling the flask in ice. The reaction mixture is stirred at ambient temperature for one week. A minimum of 30% sodium hydroxide solution (a few drops) is added to the reaction mixture to form the precipitates of lithium and aluminium hydroxides. The precipitates are then filtered off and washed with ethyl acetate. The organic phase is dried over magnesium sulphate, filtered and evaporated under reduced pressure. The oil obtained is taken up in ether saturated with HCl(g). The precipitate formed is suction-filtered off and recrystallised from acetonitrile to yield the title product in the form of a white solid.

Provenance & Evidence