Hydrochloric Acid → HCID 21094269, compound

Participants

Reaction Steps

The hydrochloride of the compound obtained in Step C (0.60 g; 0.0024 mol) is dissolved in 10 ml of a saturated aqueous potassium carbonate solution and 40 ml of dichloromethane. Tetrabutylammonium bromide (2 g; 0.006 mol) and potassium cyanide (0.80 g; 0.012 mol) are then added to the preceding solution. The reaction mixture is stirred at ambient temperature for 24 hours. The solution is extracted with dichloromethane, and the organic phase is washed with water, dried over magnesium sulphate, filtered and evaporated. The oil obtained is taken up in acetone and in ether saturated with HCl(g). The precipitate formed is suction-filtered off and recrystallised from toluene/cyclohexane, 5/5, to yield the title compound in the form of a yellow solid.

Provenance & Evidence