Methylamine → HCID 11448282, compound

Participants

Reaction Steps

The compound obtained in Step A (2.2 g; 7 mmol) is dissolved in 30 ml of methylamine (40% in water) and the mixture is heated at reflux for 3 hours with stirring. The reaction mixture is taken up in 50 ml of water and extracted with ether. The organic phase is washed with water, dried over magnesium sulphate, filtered and evaporated under reduced pressure. The oil obtained is purified by chromatography on silica gel (eluant: dichloromethane with the progressive addition of methanol). The oil obtained is evaporated under reduced pressure and the precipitate so formed is recrystallised from toluene to yield the title product in the form of a white solid.

Provenance & Evidence