HCID 131726433, compound → HCID 91055345, compound

Participants

Reaction Steps

The compound of EXAMPLE 10 (120 mg) was dissolved in a 5% sodium hydrogen carbonate solution (10 mL) and extracted with AcOEt (15 mL). The organic layer was dried and concentrated in vacuo to give 1-(4-fluoro-2-methyl-phenyl)-piperazine-2-carboxylic acid (3,5-dibromo-benzyl)-methylamide (94 mg). This material was separated into enantiomers by HPLC (conditions: column Chiralcel OD 25 cm×20 mm, mobile phase n-hexane/EtOH 80:20, flow 7 mL/min; detector DAD, λ=225 nm). Thus, 1-(4-fluoro-2-methyl-phenyl)-piperazine-2-carboxylic acid (3,5-dibromo-benzyl)-methylamide was obtained as:

Provenance & Evidence