3-Chloro-4-fluoroaniline → N-(3-Chloro-4-fluorophenyl)-2-(3,5-dimethyl-1H-pyrrol-2-yl)-2-(2-oxo-1,2-dihydroindol-3-ylidene)-acetamide

HRID 1350181Notes

Reaction equation

HRID 1350181 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][C:3]=1[C:8](=[C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][C:13]1=[O:21])[C:9](O)=[O:10].[Cl:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][C:29]=1[F:30])[NH2:26]>>[Cl:22][C:23]1[CH:24]=[C:25]([NH:26][C:9](=[O:10])[C:8]([C:3]2[NH:4][C:5]([CH3:7])=[CH:6][C:2]=2[CH3:1])=[C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][C:13]2=[O:21])[CH:27]=[CH:28][C:29]=1[F:30]

Participants

3

Reactant 2

HCID 97083-Chloro-4-fluoroanilineHCID 69453471HCID 69453471, compound

Product 1

HCID 69507230N-(3-Chloro-4-fluorophenyl)-2-(3,5-dimethyl-1H-pyrrol-2-yl)-2-(2-oxo-1,2-dihydroindol-3-ylidene)-acetamide

Procedure

(3,5-Dimethyl-1H-pyrrol-2-yl)-(2-oxo-1,2-dihydroindol-3-ylidene)-acetic acid (90 mg) was reacted with 3-chloro-4-fluoroaniline (90 mg) using method B to give the title compound.

Sources & evidence

ORD record
ord-03c92ad367dc4c5cb8c028d59d0a0b00
Source dataset
uspto-grants-2007_05
Patent number
US07214700B2

Reaction notes

Loading…