3,4-Dimethoxyaniline → HCID 69507377, compound

Participants

Reaction Steps

A mixture of (5-bromo-2-oxo-1,2-dihydroindol-3-ylidene)phenyl-acetic acid (70 mg), 3,4-dimethoxyaniline (63 mg), 4-dimethylaminopyridine (25 mg), benzotriazol-1-yloxy-tris (dimethylamino) phosphonium hexafluorophosphate (BOP, 90 mg) and TEA (1 drop) in DMF (2 mL) was refluxed overnight. The reaction mixture was concentrated and then diluted with aqueous carbonate. The precipitate which formed was washed with dilute HCl and water and then dried to give 16 mg of the title compound.

Provenance & Evidence