tert-butyl(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate → HCID 178451086, compound

HRID 1350206Notes

Reaction equation

HRID 1350206 reaction equation
[NH2:1][CH2:2][C:3]1[N:7]=[C:6]([C@H:8]([CH2:17][CH2:18][CH2:19][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[O:5][N:4]=1.[N:26]1[N:27]=[C:28]([S:31](Cl)(=[O:33])=[O:32])[NH:29][CH:30]=1>>[CH:20]1([CH2:19][CH2:18][CH2:17][C@@H:8]([C:6]2[O:5][N:4]=[C:3]([CH2:2][NH:1][S:31]([C:28]3[NH:29][CH:30]=[N:26][N:27]=3)(=[O:33])=[O:32])[N:7]=2)[CH2:9][C:10]([O:12][C:13]([CH3:15])([CH3:16])[CH3:14])=[O:11])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 16747946tert-butyl(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoateHCID 178527438HCID 178527438, compound

Product 1

HCID 178451086HCID 178451086, compound

Procedure

Method as for preparation 10 using tert-butyl(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate (preparation 18) (292 mg, 0.83 mmol) and 4H-1,2,4-triazole-3-sulfonyl chloride (preparation 24) (208 mg, 1.24 mmol) as starting materials.

Sources & evidence

ORD record
ord-e77ae41199104723bd889681dc0d6bc9
Source dataset
uspto-grants-2007_05
Patent number
US07214694B2

Reaction notes

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