HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-tert-butylsulfamoyl chloride → tert-butyl(3R)-3-[3-({[(tert-butylamino)sulfonyl]amino}methyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-tert-butylsulfamoyl chloride | HCID 12682606 | — |
| Reactant | tert-butyl(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate | HCID 16747946 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | tert-butyl(3R)-3-[3-({[(tert-butylamino)sulfonyl]amino}methyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate | HCID 60077597 | — |
Reaction Steps
Method as for preparation 10 using tert-butyl(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate (preparation 18) (200 mg, 0.57 mmol) and N-tert-butylsulfamoyl chloride (J. Org. Chem.; 1976, 41, 4028) (108 mg, 0.63 mmol) as starting materials and pyridine as base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07214694B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0557e89aa7944e69bfa84f4281e71251 |
| Source note | uspto-grants-2007_05 |