Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 2-[4-(Methanesulfonyl)phenyl]-3-(oxan-4-yl)propanoic acid | HCID 21094004 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10408333 | HCID 10408333 | — |
Reaction Steps
EDCI (80 mg, 420 μmol) and HOBt (56 mg, 420 μmol) were added to a stirred solution of 2-(4-methanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid (Preparation 41, 100 mg, 320 μmol) in anhydrous DMF (6 mL). After 15 min, the solution was treated with thiazol-2-ylamine (38 mg, 380 μmol). The mixture was stirred at 20° C. for 16 h, before being concentrated under reduced pressure. The residue was partitioned between CH2Cl2 and saturated aqueous Na2CO3. The organic layer was washed with 1M HCl and dried (MgSO4). Filtration and solvent evaporation yielded the title compound: RTA=3.16 min; m/z (ES+)=436.2 [M+MeCN+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07214681B2 |
|---|
| Source dataset | uspto-grants-2007_05 |
|---|
| ORD ID | ord-58a467247c0d46189309d792e6160792 |
|---|
| Source note | uspto-grants-2007_05 |
|---|
