HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Olanzamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 10H-Thieno[2,3-b][1,5]benzodiazepin-4-amine, 2-methyl-, hydrochloride (1:1) | HCID 135525650 | — |
| Solvent | Water | HCID 962 | — |
| Product | Olanzamine | HCID 135446208 | 92.4% |
Reaction Steps
Slurry 2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene-10-ylamine hydrochloride (5.2 g, 19.5 mmol) in water and add 1N sodium hydroxide (19.5 mL, 19.5 mmol). Add methanol to facilitate stirring and extract with methylene chloride. Purify the methylene chloride extracts by silica gel chromatography using 7N ammonia in methanol-methylene chloride (5%) as the eluent to give (4.13 g, 92%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07214673B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-646e9e5d86c443388098ec0642ff6cb1 |
| Source note | uspto-grants-2007_05 |