(S)-2-(2-(4-Fluoro-phenyl)-ethyl)-piperazine → (S)-10-{3-[2-(4-Fluoro-phenyl)-ethyl]-piperazin-1-yl}-2-methyl-4H-3-thia-1,4,9-triaza-benzo[f]azulene

Participants

Reaction Steps

By a similar method to the method of Example 460, using 2-methyl4H-3-thia-1,4,9-triaza-benzo[f]azulen-10-ylamine(1.21 g, 5.25 mmol) and (S)-2-[2-(4-fluoro-phenyl)-ethyl]-piperazine (1.09 g, 5.25 mmol) to give 0.848 g of the title compound as a tan solid: mass spectrum (ion spray): m/z=422 (M+1); Analysis for C23H24FN5S(0.3 H2O): calcd: C, 64.70; H, 5.81; N, 16.40; found: C, 64.97; H, 5.86; N, 16.15.

Provenance & Evidence