(S)-2-Benzylpiperazine → (S)-10-(3-Benzyl-piperazin-1-yl)-2-isopropyl-4H-3-thia-1,4,9-triaza-benzo[f]azulene

HRID 1350460Notes

Reaction equation

HRID 1350460 reaction equation
[CH:1]([C:4]1[S:13][C:12]2[NH:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[N:8]=[C:7]([NH2:18])[C:6]=2[N:5]=1)([CH3:3])[CH3:2].[CH2:19]([C@H:26]1[CH2:31]N[CH2:29][CH2:28][NH:27]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([C@@H:26]1[NH:27][CH2:28][CH2:29][N:18]([C:7]2[C:6]3[N:5]=[C:4]([CH:1]([CH3:3])[CH3:2])[S:13][C:12]=3[NH:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[N:8]=2)[CH2:31]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 20760001(S)-2-BenzylpiperazineHCID 1357977402-isopropyl-4H-3-thia-1,4,9-triaza-benzo[f]azulen-10-ylamine

Product 1

HCID 136005546(S)-10-(3-Benzyl-piperazin-1-yl)-2-isopropyl-4H-3-thia-1,4,9-triaza-benzo[f]azuleneYield 25.3%

Procedure

By using a similar method of the method of Example 460, using 2-isopropyl-4H-3-thia-1,4,9-triaza-benzo[f]azulen-10-ylamine(1.44 g, 5.5 mmol) and (S)-2-benzyl-piperazine (0.983 g, 5.5 mmol) to give 0.580 g of the title compound as a yellow solid: mass spectrum (ion spray): m/z=418 (M+1); Analysis for C24H27N5S(0.2 H2O): calcd: C, 68.44; H, 6.56; N, 16.63; found: C, 68.63; H, 6.43; N, 16.74.

Sources & evidence

ORD record
ord-2172415d431f45dbb395ccbdad0e8afb
Source dataset
uspto-grants-2007_05
Patent number
US07214673B2

Reaction notes

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