HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1350550Generated: October 31, 2026
Hydrochloric Acid → 1-[2-(Benzimidazol-2-ylthio)ethyl]piperazine
https://huagongshe.com/reaction/1350550
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 1-Formyl-4-[2-(benzimidazol-2-ylthio)ethyl]piperazine | HCID 9961788 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[2-(Benzimidazol-2-ylthio)ethyl]piperazine | HCID 9961787 | 137.2% |
Reaction Steps
1-[2-(benzimidazol-2-ylthio)ethyl]-4-formylpiperazine (1.92 kg) was suspended in methanol (4.5 kg), and 12N hydrochloric acid (2.9 kg) was added, and the mixture was stirred at 40° C. for 3 hours. To the reaction solution was added chloroform (17 kg), and the precipitated crystals were collected by filtration. The crystals were washed with chloroform to give 2.38 kg of 1-[2-(benzimidazol-2-ylthio)ethyl]piperazine.3 hydrochloride (yield 97%) as colorless crystalline powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07214796B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-f83b8544d867473abb883e79f8bd0d5d |
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| Source note | uspto-grants-2007_05 |
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