p-Toluenesulfonic acid → HCID 178445628, compound

Participants

Reaction Steps

A toluene (100 ml) solution of 7-ethoxy-3-[2-[trans-4-(trans-4-butylcyclohexyl)cyclohexyl]-1-hydroxyethyl]-1,2,8-trifluoronaphthalene and p-toluenesulfonic acid (0.6 g) was refluxed with heating in an autoclave for 1 hour. The reaction solution was washed with water and brine, and concentrated. The crude production of (E)-7-ethoxy-3-[2-[trans-4-(trans-4-butylcyclohexyl)cyclohexyl]ethenyl]-1,2,8-trifluoronaphthalene (16.6 g) was obtained.

Provenance & Evidence