5-Tert-butyl-2-methyl-pyridin-3-ylamine → N-(5-tert-Butyl-2-methyl-pyridin-3-yl)-3-{4-[6-(cyclopropylmethyl-amino)-pyridin-3-yl]-[1,2,3]triazol-1-yl}-4-methyl-benzamide

HRID 1350646Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1350646
[CH:1]1([CH2:4][NH:5][C:6]2[N:11]=[CH:10][C:9]([C:12]3[N:13]=[N:14][N:15]([C:17]4[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=4[CH3:26])[C:20]([OH:22])=O)[CH:16]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.[C:27]([C:31]1[CH:32]=[C:33]([NH2:38])[C:34]([CH3:37])=[N:35][CH:36]=1)([CH3:30])([CH3:29])[CH3:28]>>[C:27]([C:31]1[CH:32]=[C:33]([NH:38][C:20](=[O:22])[C:19]2[CH:23]=[CH:24][C:25]([CH3:26])=[C:17]([N:15]3[CH:16]=[C:12]([C:9]4[CH:10]=[N:11][C:6]([NH:5][CH2:4][CH:1]5[CH2:3][CH2:2]5)=[CH:7][CH:8]=4)[N:13]=[N:14]3)[CH:18]=2)[C:34]([CH3:37])=[N:35][CH:36]=1)([CH3:30])([CH3:29])[CH3:28]

Komponenten

3

Edukt 2

HCID 210243035-Tert-butyl-2-methyl-pyridin-3-ylamineHCID 210972943-{4-[6-(Cyclopropylmethyl-amino)-pyridin-3-yl]-1,2,3-triazol-1-yl}-4-methyl-benzoic acid

Produkt 1

HCID 21097108N-(5-tert-Butyl-2-methyl-pyridin-3-yl)-3-{4-[6-(cyclopropylmethyl-amino)-pyridin-3-yl]-[1,2,3]triazol-1-yl}-4-methyl-benzamide

Versuchsvorschrift

Example 2 was prepared by coupling 3-{4-[6-(cyclopropylmethyl-amino)-pyridin-3-yl]-1,2,3-triazol-1-yl}-4-methyl-benzoic acid with 5-tert-butyl-2-methyl-pyridin-3-ylamine (See U.S. provisional application 60/567,693) in the same manner as Example 1. ESI MS m/z 496 [C29H33N7O+H]+.

Aufarbeitung

  1. customExample 2 was prepared

Quellen und Nachweise

ORD-Eintrag
ord-8f2e17e4a63e41d883a01fd4063a315f
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07214802B2

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