5-Ethynyl-2-methylpyridine → 4-Methyl-3-[4-(6-methyl-pyridin-3-yl)-[1,2,3]triazol-1-yl]-benzoic acid

HRID 1350653Notes

Reaction equation

HRID 1350653 reaction equation
[N:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[CH3:13])[C:7]([OH:9])=[O:8])=[N+:2]=[N-:3].[CH3:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]#[CH:22])=[CH:17][N:16]=1.ClC1N=CC(C2N=NN(C3C=C(C=CC=3C)C(O)=O)C=2)=CC=1>>[CH3:13][C:12]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[N:1]1[CH:22]=[C:21]([C:18]2[CH:17]=[N:16][C:15]([CH3:14])=[CH:20][CH:19]=2)[N:3]=[N:2]1

Participants

4

Reactant 3

HCID 6381975-Ethynyl-2-methylpyridineHCID 179730913-Azido-4-methylbenzoic acidHCID 210972923-[4-(6-Chloro-pyridin-3-yl)-1,2,3-triazol-1-yl]-4-methyl-benzoic acid

Product 1

HCID 210973284-Methyl-3-[4-(6-methyl-pyridin-3-yl)-[1,2,3]triazol-1-yl]-benzoic acid

Procedure

4-Methyl-3-[4-(6-methyl-pyridin-3-yl)-[1,2,3]triazol-1-yl]-benzoic acid was prepared from 3-azido-4-methyl benzoic acid and 2-methyl-5-ethynyl pyridine in the same manner as 3-[4-(6-chloro-pyridin-3-yl)-1,2,3-triazol-1-yl]-4-methyl-benzoic acid (Example 1).

Sources & evidence

ORD record
ord-ac5447edaae74d83940844b598f5af5e
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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