HRID1350666

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cncc(-c2cn(-c3cc(C(=O)O)ccc3C)nn2)c1

HCID21097291

未命名化合物

HCID22025264

未命名化合物

PRODUCTS

生成物

结构：COc1cncc(-c2cn(-c3cc(C(=O)Nc4cc(C5(C)CC5)cc(NS(C)(=O)=O)c4OC)ccc3C)nn2)c1

HCID21097097

未命名化合物

PROCEDURE

实验过程

Example 12 was prepared by coupling 3-[4-(5-methoxy-pyridin-3-yl)-[1,2,3]triazol-1-yl]-4-methyl-benzoic acid with N-[3-amino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-methanesulfonamide (U.S. Ser. No. 04/102,492) in the same manner as Example 1. ESI MS m/z 563 [C28H30N6O5S+H]+.

WORKUP

后处理

customExample 12 was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3cfc15fd7cda47708f51f3390a07dff0
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07214802B2
来源说明: uspto-grants-2007_05

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[N:11][N:12]([C:14]3[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=3[CH3:23])[C:17](O)=[O:18])[CH:13]=2)[CH:6]=[N:7][CH:8]=1.[NH2:24][C:25]1[C:26]([O:40][CH3:41])=[C:27]([NH:35][S:36]([CH3:39])(=[O:38])=[O:37])[CH:28]=[C:29]([C:31]2([CH3:34])[CH2:33][CH2:32]2)[CH:30]=1>>[CH3:39][S:36]([NH:35][C:27]1[C:26]([O:40][CH3:41])=[C:25]([NH:24][C:17](=[O:18])[C:16]2[CH:20]=[CH:21][C:22]([CH3:23])=[C:14]([N:12]3[CH:13]=[C:9]([C:5]4[CH:6]=[N:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=4)[N:10]=[N:11]3)[CH:15]=2)[CH:30]=[C:29]([C:31]2([CH3:34])[CH2:32][CH2:33]2)[CH:28]=1)(=[O:38])=[O:37]