3-Ethynylpyridine → N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-fluoro-4-methyl-5-(4-pyridin-3-yl-[1,2,3]triazol-1-yl)-benzamide

HRID 1350682Notes

Reaction equation

HRID 1350682 reaction equation
[N:1]([C:4]1[CH:5]=[C:6]([CH:27]=[C:28]([F:31])[C:29]=1[CH3:30])[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:13]=[C:12]([NH:20][S:21]([CH3:24])(=[O:23])=[O:22])[C:11]=1[O:25][CH3:26])=[O:8])=[N+:2]=[N-:3].[C:32]([C:34]1[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=1)#[CH:33]>>[C:16]([C:14]1[CH:13]=[C:12]([NH:20][S:21]([CH3:24])(=[O:22])=[O:23])[C:11]([O:25][CH3:26])=[C:10]([NH:9][C:7](=[O:8])[C:6]2[CH:5]=[C:4]([N:1]3[CH:33]=[C:32]([C:34]4[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=4)[N:3]=[N:2]3)[C:29]([CH3:30])=[C:28]([F:31])[CH:27]=2)[CH:15]=1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 1860033-EthynylpyridineHCID 179730683-Azido-N-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-5-fluoro-4-methyl-benzamide

Product 1

HCID 21097182N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-fluoro-4-methyl-5-(4-pyridin-3-yl-[1,2,3]triazol-1-yl)-benzamide

Procedure

Example 21 was prepared from 3-azido-N-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-5-fluoro-4-methyl-benzamide and 3-ethynyl-pyridine in the same manner as Example 15. ESI MS m/z 553 [C27H29FN6O4S+H]+.

Sources & evidence

ORD record
ord-5732757601d04d818a82c25172e34927
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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