5-Bromo-2-methoxypyridine → 5-Ethynyl-2-methoxypyridine

HRID 1350683Notes

Reaction equation

HRID 1350683 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Cl[C:11]1[CH:16]=CC(C#C)=CN=1>>[C:11]([C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1)#[CH:16]

Participants

3

Reactant 2

HCID 27348955-Bromo-2-methoxypyridineHCID 106542812-Chloro-5-ethynylpyridine

Product 1

HCID 210973485-Ethynyl-2-methoxypyridine

Procedure

5-Ethynyl-2-methoxy pyridine was prepared from 5-bromo-2-methoxy-pyridine (Aldrich) in the same manner as 2-chloro-5-ethynyl-pyridine (Example 1).

Sources & evidence

ORD record
ord-c3f55fbe026b479c82b91d52a4a6b352
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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