3-Bromo-5-methoxypyridine → 3-Ethynyl-5-methoxypyridine

HRID 1350685Notes

Reaction equation

HRID 1350685 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[N:6][CH:7]=1.Cl[C:11]1[CH:16]=CC(C#C)=CN=1>>[C:11]([C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[N:6][CH:7]=1)#[CH:16]

Participants

3

Reactant 2

HCID 8171633-Bromo-5-methoxypyridineHCID 106542812-Chloro-5-ethynylpyridine

Product 1

HCID 210973493-Ethynyl-5-methoxypyridine

Procedure

5-Ethynyl-3-methoxy pyridine was prepared from 5-bromo-3-methoxy-pyridine (Frontier) in the same manner as 2-chloro-5-ethynyl-pyridine (Example 1).

Sources & evidence

ORD record
ord-45db36e0f76e44018ae9940357cf09e6
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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