Benzoyl chloride → (5-Ethynyl-1-methyl-1H-imidazol-2-yl)-phenyl-methanone

HRID 1350706Notes

Reaction equation

BrC1N(C)C=NC=1.[C:8](Cl)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(C1C=C(NS(C)(=O)=O)C(OC)=C(NC(=O)C2C=CC(C)=C(N3[CH:40]=[C:39]([C:41]4[N:42]([CH3:50])[C:43](C(O)(C)C)=[N:44][CH:45]=4)N=N3)C=2)C=1)(C)(C)C>>[C:39]([C:41]1[N:42]([CH3:50])[C:43]([C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:15])=[N:44][CH:45]=1)#[CH:40]

Participants

Reactant 3

HCID 7412Benzoyl chloride

HCID 15152585-Bromo-1-methyl-1H-imidazole

HCID 21097129N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-{4-[2-(1-hydroxy-1-methyl-ethyl)-3-methyl-3H-imidazol-4-yl]-[1,2,3]triazol-1-yl}-4-methyl-benzamide

Product 1

HCID 21097345(5-Ethynyl-1-methyl-1H-imidazol-2-yl)-phenyl-methanone

Procedure

(5-Ethynyl-1-methyl-1H-imidazol-2-yl)-phenyl-methanone was prepared from 5-bromo-1-methyl imidazole and benzoyl chloride in the same manner as 1-methyl-5-ethynyl-1H-imidazole-2-carboxylic acid ethyl ester (Example 27).

Sources & evidence

ORD record: ord-ab657ef0ada04a9cacc0e732e850d1a9
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07214802B2

Reaction notes

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