HRID1350720

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1c(NC(=O)c2ccc(C)c(N=[N+]=[N-])c2)cc(C(C)(C)C)cc1NS(C)(=O)=O

HCID21079202

未命名化合物

PRODUCTS

生成物

结构：COc1c(NC(=O)c2ccc(C)c(-n3cc(-c4cn(C)c(C5CC5)n4)nn3)c2)cc(C(C)(C)C)cc1NS(C)(=O)=O

HCID21097138

未命名化合物

PROCEDURE

实验过程

Example 47 was prepared from 2-cyclopropyl-1-methyl-1H-imidazole-4-carbaldehyde (as a 1:1 mixture with 2-cyclopropyl-3-methyl-3H-imidazole-4-carbaldehyde) and 3-azido-N-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-benzamide in the same manner as Example 39. Chromatography allowed separation of Example 47 from Example 46. ESI MS m/z 578 [C29H35N7O4S+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2b50039af1154a5b84e15c2e96d48bf1
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07214802B2
来源说明: uspto-grants-2007_05

反应 SMILES

[CH:1]1([C:4]2[N:5]([CH3:11])[CH:6]=[C:7]([CH:9]=O)[N:8]=2)[CH2:3][CH2:2]1.C1(C2N(C)C(C=O)=CN=2)CC1.N(C1C=C(C=CC=1C)C(NC1C=C(C(C)(C)C)C=C(NS(C)(=O)=O)C=1OC)=O)=[N+]=[N-].[C:53]([C:57]1[CH:58]=[C:59]([NH:89][S:90]([CH3:93])(=[O:92])=[O:91])[C:60]([O:87][CH3:88])=[C:61]([NH:63][C:64](=[O:86])[C:65]2[CH:70]=[CH:69][C:68]([CH3:71])=[C:67]([N:72]3[CH:76]=C(C4N(C)C(C5CC5)=NC=4)[N:74]=[N:73]3)[CH:66]=2)[CH:62]=1)([CH3:56])([CH3:55])[CH3:54]>>[C:53]([C:57]1[CH:58]=[C:59]([NH:89][S:90]([CH3:93])(=[O:91])=[O:92])[C:60]([O:87][CH3:88])=[C:61]([NH:63][C:64](=[O:86])[C:65]2[CH:70]=[CH:69][C:68]([CH3:71])=[C:67]([N:72]3[CH:76]=[C:9]([C:7]4[N:8]=[C:4]([CH:1]5[CH2:3][CH2:2]5)[N:5]([CH3:11])[CH:6]=4)[N:74]=[N:73]3)[CH:66]=2)[CH:62]=1)([CH3:56])([CH3:54])[CH3:55]