Isopropylamine → 3-Isopropyl-2-methyl-3H-imidazole-4-carbaldehyde

HRID 1350726Notes

Reaction equation

Cl.C(=N)(OCC)C.C(N)(C)C.[CH:12]1([N:15]2[C:19]([CH:20]=[O:21])=[CH:18][N:17]=[C:16]2[CH3:22])[CH2:14][CH2:13]1>>[CH:12]([N:15]1[C:19]([CH:20]=[O:21])=[CH:18][N:17]=[C:16]1[CH3:22])([CH3:14])[CH3:13]

Participants

Reactant 3

HCID 6363Isopropylamine

HCID 2724290Ethanimidic acid, ethyl ester, hydrochloride (1:1)

HCID 210973073-cyclopropyl-2-methyl-3H-imidazole-4-carbaldehyde

Product 1

HCID 210973093-Isopropyl-2-methyl-3H-imidazole-4-carbaldehyde

Procedure

3-Isopropyl-2-methyl-3H-imidazole-4-carbaldehyde was prepared from ethyl acetimidate hydrochloride and isopropylamine in the same manner as 3-cyclopropyl-2-methyl-3H-imidazole-4-carbaldehyde (Example 45).

Sources & evidence

ORD record: ord-0652540a2bf141d8a8070ac427f25663
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07214802B2

Reaction notes

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