Methyl acetoacetate → 1-Isopropyl-5-methyl-1H-pyrazole-4-carbaldehyde

HRID 1350727Notes

Reaction equation

C(OC)(=O)CC(C)=O.Cl.C(NN)(C)C.[CH:15]1([C:18]2[N:22]([CH:23]([CH3:25])[CH3:24])[N:21]=[CH:20][C:19]=2[CH:26]=[O:27])CC1>>[CH:23]([N:22]1[C:18]([CH3:15])=[C:19]([CH:26]=[O:27])[CH:20]=[N:21]1)([CH3:25])[CH3:24]

Participants

Reactant 3

HCID 7757Methyl acetoacetate

HCID 855731-Isopropylhydrazine hydrochloride

HCID 196201355-cyclopropyl-1-(propan-2-yl)-1H-pyrazole-4-carbaldehyde

Product 1

HCID 196200991-Isopropyl-5-methyl-1H-pyrazole-4-carbaldehyde

Procedure

1-Isopropyl-5-methyl-1H-pyrazole-4-carbaldehyde was prepared with methyl acetoacetate and isopropyl hydrazine hydrochloride in the same manner as 5-cyclopropyl-1-isopropyl-1H-pyrazole-4-carbaldehyde (Example 49).

Sources & evidence

ORD record: ord-08751fae12d8421f9ffde79f90b376ef
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07214802B2

Reaction notes

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