Trimethylacetamide → 2-tert-Butyl-3-methyl-3H-imidazole-4-carbaldehyde

HRID 1350735Notes

Reaction equation

[CH3:1][C:2]([CH3:7])([CH3:6])[C:3]([NH2:5])=O.C1([C:11]2[N:15](C)[C:14]([CH:17]=[O:18])=[CH:13]N=2)CC1>>[C:2]([C:3]1[N:15]([CH3:11])[C:14]([CH:17]=[O:18])=[CH:13][N:5]=1)([CH3:7])([CH3:6])[CH3:1]

Participants

Reactant 2

HCID 12957Trimethylacetamide

HCID 210972742-cyclopropyl-3-methyl-3H-imidazole-4-carbaldehyde

Product 1

HCID 210972822-tert-Butyl-3-methyl-3H-imidazole-4-carbaldehyde

Procedure

2-tert-Butyl-3-methyl-3H-imidazole-4-carbaldehyde was prepared from trimethyl acetamide in the same manner as 2-cyclopropyl-3-methyl-3H-imidazole-4-carbaldehyde (Example 46).

Sources & evidence

ORD record: ord-45a177d59047472b8474b2ab4bdb3060
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07214802B2

Reaction notes

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