Isobutyramide → 3-Cyclopropyl-2-isopropyl-3H-imidazole-4-carbaldehyde

HRID 1350739Notes

Reaction equation

[C:1]([NH2:6])(=O)[CH:2]([CH3:4])[CH3:3].C1(N)CC1.[CH:11]1([C:14]2[N:18](C)[C:17]([CH:20]=[O:21])=[CH:16]N=2)[CH2:13]C1>>[CH:14]1([N:18]2[C:17]([CH:20]=[O:21])=[CH:16][N:6]=[C:1]2[CH:2]([CH3:4])[CH3:3])[CH2:11][CH2:13]1

Participants

Reactant 3

HCID 68424Isobutyramide

HCID 69828Cyclopropylamine

HCID 210972742-cyclopropyl-3-methyl-3H-imidazole-4-carbaldehyde

Product 1

HCID 210973063-Cyclopropyl-2-isopropyl-3H-imidazole-4-carbaldehyde

Procedure

3-Cyclopropyl-2-isopropyl-3H-imidazole-4-carbaldehyde was prepared from isobutyramide and cyclopropylamine in the same manner as 2-cyclopropyl-3-methyl-3H-imidazole-4-carbaldehyde (Example 46).

Sources & evidence

ORD record: ord-7029d454b4cd4adbad089c41ab2d3320
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07214802B2

Reaction notes

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