Ethanamine, 2,2,2-trifluoro- → HCID 21097281, compound

HRID 1350746Notes

Reaction equation

HRID 1350746 reaction equation
Cl.C(=N)(OCC)C.[F:8][C:9]([F:13])([F:12])[CH2:10][NH2:11].C1(N2[C:21]([CH:22]=[O:23])=[CH:20][N:19]=[C:18]2[CH3:24])CC1>>[CH3:24][C:18]1[N:11]([CH2:10][C:9]([F:13])([F:12])[F:8])[C:21]([CH:22]=[O:23])=[CH:20][N:19]=1

Participants

4

Reactant 3

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 2724290Ethanimidic acid, ethyl ester, hydrochloride (1:1)HCID 210973073-cyclopropyl-2-methyl-3H-imidazole-4-carbaldehyde

Product 1

HCID 21097281HCID 21097281, compound

Procedure

2-Methyl-3-(2,2,2-trifluoro-ethyl)-3H-imidazole-4-carbaldehyde was prepared from ethyl acetimidate hydrochloride and 2,2,2-trifluoroethylamine in the same manner as 3-cyclopropyl-2-methyl-3H-imidazole-4-carbaldehyde (Example 45).

Sources & evidence

ORD record
ord-2e1f5e97839c46ecb2a3b03d1d82b8fe
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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