1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid → tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

HRID 1350775Notes

Reaction equation

HRID 1350775 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=O)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].O=C(C1C=CC=CN=1)[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[C:1]([N:8]1[CH2:9][CH2:10][CH:11]([C:14](=[O:16])[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:12][CH2:13]1)([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Participants

3

Reactant 2

HCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acidHCID 2736461Ethyl 3-oxo-3-(pyridin-2-yl)propanoate

Product 1

HCID 6618868tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

Procedure

N-Boc-4-(2-Ethoxycarbonyl-acetyl)-piperidine was prepared from N-Boc-piperidine-4-carboxylic acid in the same manner as ethyl 3-oxo-3-pyridin-2-yl-propionate (Example 94).

Sources & evidence

ORD record
ord-c2d93b0f1ef34faf9dc787604c7a573b
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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