tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate → N-Boc-4-(2-Cyclopropyl-4-ethoxycarbonyl-2H-pyrazol-3-yl)-piperidine

HRID 1350776Notes

Reaction equation

[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=O)[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[C:22](O)(=O)C(O)=O.[CH:28]1([NH:31][NH2:32])[CH2:30][CH2:29]1.C(C1C=C(NS(C)(=O)=O)C(OC)=C(NC(=O)C2C=CC(C)=C(N3C=C(C4C=NN(C(C)C)C=4C4CC4)N=N3)C=2)C=1)(C)(C)C>>[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:31]([CH:28]3[CH2:30][CH2:29]3)[N:32]=[CH:22][C:15]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

Reactant 3

HCID 6618868tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

HCID 21097161N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3-[4-(5-cyclopropyl-1-isopropyl-1H-pyrazol-4-yl)-[1,2,3]triazol-1-yl]-4-methyl-benzamide

HCID 67509750Cyclopropylhydrazine oxalate

Product 1

HCID 21097372N-Boc-4-(2-Cyclopropyl-4-ethoxycarbonyl-2H-pyrazol-3-yl)-piperidine

Procedure

N-Boc-4-(2-Cyclopropyl-4-ethoxycarbonyl-2H-pyrazol-3-yl)-piperidine was prepared from N-Boc-4-(2-ethoxycarbonyl-acetyl)-piperidine and cyclopropyl hydrazine oxalate in the same manner as 5-cyclopropyl-1-isopropyl-1H-pyrazole-4-carboxylic acid ethyl ester (Example 49).

Sources & evidence

ORD record: ord-8313139cfa8f49e6a696d37261aad93a
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07214802B2

Reaction notes

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