HRID1350791

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1c(NC(=O)c2ccc(C)c(-n3cc(-c4cnc(C5CC5)n4C)nn3)c2)cc(C(C)(C)CO)cc1NS(C)(=O)=O

HCID21097080

未命名化合物

HCID21097346

未命名化合物

PRODUCTS

生成物

结构：COc1c(NC(=O)c2ccc(C)c(-n3cc(-c4cnc(C5(C)CC5)n4C)nn3)c2)cc(C(C)(C)CO)cc1NS(C)(=O)=O

HCID21097101

未命名化合物

PROCEDURE

实验过程

Example 134 was prepared in the same manner as 3-[4-(2-cyclopropyl-3-methyl-3H-imidazol-4-yl)-1,2,3-triazol-1-yl]-N-[5-(2-hydroxy-1,1-dimethyl-ethyl)-3-methane-sulfonylamino-2-methoxy-phenyl]-4-methyl-benzamide (Example 133) with 1.5 equivalents of 5-ethynyl-1-methyl-2-(1-methyl-cyclopropyl)-1H-imidazole. ESI MS m/z 608 [C30H37N7O5S+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7788f8851e9343f88b5614884ab667d2
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07214802B2
来源说明: uspto-grants-2007_05

反应 SMILES

[CH:1]1([C:4]2[N:8]([CH3:9])[C:7]([C:10]3[N:11]=[N:12][N:13]([C:15]4[CH:16]=[C:17]([CH:39]=[CH:40][C:41]=4[CH3:42])[C:18]([NH:20][C:21]4[CH:26]=[C:25]([C:27]([CH3:31])([CH3:30])[CH2:28][OH:29])[CH:24]=[C:23]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])[C:22]=4[O:37][CH3:38])=[O:19])[CH:14]=3)=[CH:6][N:5]=2)[CH2:3][CH2:2]1.[C:43](C1N(C)C(C2(C)CC2)=NC=1)#C>>[OH:29][CH2:28][C:27]([C:25]1[CH:24]=[C:23]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])[C:22]([O:37][CH3:38])=[C:21]([NH:20][C:18](=[O:19])[C:17]2[CH:39]=[CH:40][C:41]([CH3:42])=[C:15]([N:13]3[CH:14]=[C:10]([C:7]4[N:8]([CH3:9])[C:4]([C:1]5([CH3:43])[CH2:3][CH2:2]5)=[N:5][CH:6]=4)[N:11]=[N:12]3)[CH:16]=2)[CH:26]=1)([CH3:31])[CH3:30]