3-Amino-5-(tert-butyl)-2-methoxybenzonitrile → N-(5-tert-Butyl-3-cyano-2-methoxy-phenyl)-3-[4-(5-ethyl-1-phenyl-1H-pyrazol-4-yl)-imidazol-1-yl]-4-methyl-benzamide

HRID 1350803Notes

Reaction equation

HRID 1350803 reaction equation
[NH2:1][C:2]1[C:3]([O:14][CH3:15])=[C:4]([CH:7]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:9]=1)[C:5]#[N:6].C[O:17][C:18](=O)[C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[C:21]([N:26]2[CH:30]=[C:29]([C:31]3[CH:32]=[N:33][N:34]([C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[C:35]=3[CH2:36][CH3:37])[N:28]=[CH:27]2)[CH:20]=1>>[C:10]([C:8]1[CH:7]=[C:4]([C:5]#[N:6])[C:3]([O:14][CH3:15])=[C:2]([NH:1][C:18](=[O:17])[C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[C:21]([N:26]3[CH:30]=[C:29]([C:31]4[CH:32]=[N:33][N:34]([C:38]5[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=5)[C:35]=4[CH2:36][CH3:37])[N:28]=[CH:27]3)[CH:20]=2)[CH:9]=1)([CH3:12])([CH3:11])[CH3:13]

Participants

3

Reactant 2

HCID 210972973-Amino-5-(tert-butyl)-2-methoxybenzonitrileHCID 588614453-[4-(5-ethyl-1-phenyl-1H-pyrazol-4-yl)-imidazol-1-yl]-4-methyl-benzoic acid methyl ester

Product 1

HCID 21097111N-(5-tert-Butyl-3-cyano-2-methoxy-phenyl)-3-[4-(5-ethyl-1-phenyl-1H-pyrazol-4-yl)-imidazol-1-yl]-4-methyl-benzamide

Procedure

Example 155 was prepared from 3-amino-5-tert-butyl-2-methoxy-benzonitrile and 3-[4-(5-ethyl-1-phenyl-1H-pyrazol-4-yl)-imidazol-1-yl]-4-methyl-benzoic acid methyl ester (Example 151) in the same manner as Example 151. ESI MS m/z 559 [C34H34N6O2+H]+.

Sources & evidence

ORD record
ord-e76f18c514c444f2b15f39a4c4ce265a
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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