1H-Imidazolium, 2-chloro-4,5-dihydro-1,3-dimethyl-, chloride → 2-(4-tert-Butyl-3-fluorophenoxy)-N-(3-fluoro-4-[(methylsulfonyl)amino]benzyl}acetamide

HRID 1350824노트

반응식

HRID 1350824 반응식
[C:1]([C:5]1[CH:15]=[CH:14][C:8]([O:9][CH2:10][C:11]([OH:13])=O)=[CH:7][C:6]=1[F:16])([CH3:4])([CH3:3])[CH3:2].[Cl-].ClC1N(C)CC[NH+]1C.Cl.[NH2:27][CH2:28][C:29]1[CH:34]=[CH:33][C:32]([NH:35][S:36]([CH3:39])(=[O:38])=[O:37])=[C:31]([F:40])[CH:30]=1>C(N(CC)CC)C>[C:1]([C:5]1[CH:15]=[CH:14][C:8]([O:9][CH2:10][C:11]([NH:27][CH2:28][C:29]2[CH:34]=[CH:33][C:32]([NH:35][S:36]([CH3:39])(=[O:38])=[O:37])=[C:31]([F:40])[CH:30]=2)=[O:13])=[CH:7][C:6]=1[F:16])([CH3:2])([CH3:3])[CH3:4]

참가 물질

5

반응물 3

HCID 109867151H-Imidazolium, 2-chloro-4,5-dihydro-1,3-dimethyl-, chlorideHCID 21097504(4-tert-Butyl-3-fluorophenoxy)acetic acidHCID 21097525N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride

생성물 1

HCID 115754872-(4-tert-Butyl-3-fluorophenoxy)-N-(3-fluoro-4-[(methylsulfonyl)amino]benzyl}acetamide수율 8.4%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

Crude (4-tert-butyl-3-fluorophenoxy)acetic acid (124 mg, crude), 2-chloro-1,3-dimethylimidazolinium chloride (CDI) (90 mg, 0.55 mmol), triethylamine (0.35 ml) and-N[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride (127 mg, 0.5 mmol) were mixed in the same procedure described in Example 2(b) to give 18 mg (7.8% yield) of the title compound as a white solid.

출처 및 근거

ORD 기록
ord-1127de8748084a8dbbd2784e73183779
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214824B2

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