1H-Imidazolium, 2-chloro-4,5-dihydro-1,3-dimethyl-, chloride → 3-Chloro-4-(trifluoromethyl)phenoxyl-N-{3-methyl-4-[(methylsulfonyl)amino]benzyl}acetamide

Participants

Reaction Steps

[3-Chloro-4-(trifluoromethyl)phenoxy]acetic acid (127 mg, 0.5 mmol), 2-chloro-1,3-dimethylimidazolinium chloride (CDI) (97 mg, 0.6 mmol), triethylamine (0.33 ml) and N{4-(aminomethyl)-2-methylphenyl]methanesulfonamide hydrochloride (151 mg, 0.6 mmol) were treated in the same procedure described in Example 2(b). The crude residue was applied to a silica gel chromatography column and eluted with a volume mixture of hexane and ethyl acetate (3/1 to 1/1) to furnish 150 mg (67% yield) of the title compound as a white solid.

Provenance & Evidence