HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(4-tert-Butyl-2-chlorophenoxy)-N-{3-fluoro-4-[(methylsulfonyl)amino]benzyl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (4-Tert-butyl-2-chlorophenoxy)acetic acid | HCID 230818 | — |
| Reactant | 1H-Imidazolium, 2-chloro-4,5-dihydro-1,3-dimethyl-, chloride | HCID 10986715 | — |
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(4-tert-Butyl-2-chlorophenoxy)-N-{3-fluoro-4-[(methylsulfonyl)amino]benzyl}acetamide | HCID 21097454 | 7.2% |
Reaction Steps
A mixture of (4-tert-butyl-2-chlorophenoxy)acetic acid (121 mg, 0.5 mmol), 2-chloro-1,3-dimethylimidazolinium chloride (CDI) (90 mg, 0.55 mmol), triethylamine (0.30 ml), tetrahydrofuran (3.0 ml) and N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride (127 mg, 0.5 mmol) was treated in the same procedure described in Example 2(b) to give 16 mg (7% yield) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07214824B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-16c66ffa79e64cc0ba81ee536f0ca01b |
| Source note | uspto-grants-2007_05 |