Hydrochloric Acid → HCID 11687661, compound

Participants

Reaction Steps

A mixture of N-(2-chloro-4-cyanophenyl)methanesulfonamide (0.5 g, 2.2 mmol) and 10% Pd—C (100 mg) in methanol (7.5 ml)-tetrahydrofuran (7.5 ml)-12M aqueous solution of hydrogen chloride (3.0 ml) was stirred under H2 balloon pressure for 2 hours at ambient temperature. Then, filtration to remove 10% Pd—C, evaporation gave the crude residue, which was applied to recrystallization from methanol and diisopropylether to furnish 500 mg (85% yield) of title compound as a white solid.

Provenance & Evidence