Triethylamine → 2-(4-tert-Butylphenoxy)-N-{3-methoxy-4-[(methysulfonyl)amino]benzyl}acetamide

Participants

Reaction Steps

A mixture of N-[4-(aminomethyl)-3-methoxyphenyl]methanesulfonamide trifluoroacetic acid (1.24 g, 3.6 mmol), (4-tert-butylphenoxy)acetic acid (625 mg, 3.0 mmol), 1-ethyl-3-(3′-dimethylaminopropyl) carbodiimide hydrogen chloride (EDC) (1.04 g, 5.4 mmol), triethylamine (1.21 g, 2.0 mmol) and 4-(dimethylamino)pyridine (DMAP) (110 mg, 0.9 mmol) in N,N-dimethylformamide (DMF) (30 ml) was treated in the same procedure described in Example 2(b) to give 543 mg (43% yield) of the title compound as a white amorphous solid.

Provenance & Evidence