1H-Imidazolium, 2-chloro-4,5-dihydro-1,3-dimethyl-, chloride → 2-(4-tert-Butyl-3-chlorophenoxy)-N-((1R)-1-{3-fluoro-4-[(methylsulfonyl)amino]phenyl}ethyl}acetamide

Participants

Reaction Steps

(4-tert-Butyl-3-chlorophenoxy)acetic acid (121 mg, 0.50 mmol), 2-chloro-1,3-dimethylimidazolinium chloride (CDI) (86 mg, 0.53 mmol), triethylamine (0.5 ml) and N{4-[(1R)-1-aminoethyl]-2-fluorophenyl}methanesulfonamide hydrochloride (134 mg, 0.50 mmol, WO 2005003084A1) were mixed in the same procedure described in Example 2(b) to give 68 mg (30% yield) of the title compound as a white solid.

Provenance & Evidence