反应详情

To N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-methylphenyl]methanesulfonamide (530 mg,1.60 mmol) was added 10% methanolic hydrogen chloride (5.0 ml) and dioxane (5.0 ml). The solution was stirred at ambient temperature for 30 minutes and then concentrated under reduced pressure. Diethyl ether was added to precipitate amine hydrochloride. The precipitate was then filtered, washed with diethyl ether and collected to furnish 450 mg (quant.) of the title compound as a white solid.

1. concentrationconcentrated under reduced pressure
2. additionDiethyl ether was added
3. customto precipitate amine hydrochloride
4. filtrationThe precipitate was then filtered
5. washwashed with diethyl ether
6. customcollected