反应详情

To a stirred solution of 5-methoxy-1,1-dimethylindane (941 mg, 5.34 mmol) in anhydrous dichloromethane (20 ml) was added 1.0 M boron tribromide dichloromethane solution (10.7 ml, 10.7 mmol) via a syringe at −78° C. The mixture was warmed to ambient temperature and stirred for 1.5 hours. The mixture was quenched with water (15 ml) and extracted with dichloromethane. The combined solution was washed with brine, dried over sodium sulfate. After filtration to separate solvent and sodium sulfate, the solvent was removed under reduced pressure to give 878 mg of the crude 1,1-dimethylindan-5-ol as a gray solid.

1. customThe mixture was quenched with water (15 ml)
2. extractionextracted with dichloromethane
3. washThe combined solution was washed with brine
4. dry with materialdried over sodium sulfate
5. filtrationAfter filtration
6. customto separate solvent and sodium sulfate
7. customthe solvent was removed under reduced pressure