反应详情

A mixture of ethyl [(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)oxy]acetate (1.14 g, 4.58 mmol) in ethanol (20 ml) and 2M sodium hydroxide aqueous solution (4 ml) was refluxed for 2 hours. After cooling to ambient temperature, the solvent was evaporated in vacuo and the aqueous solution was acidified to pH 2 with 2M hydrochloride aqueous solution with ice-cooling. The precipitate solid was collected and dried in vacuo to give 894 mg (89% yield) of the title compound as a pale gray solid.

1. temperaturewas refluxed for 2 hours
2. customthe solvent was evaporated in vacuo
3. temperaturecooling
4. customThe precipitate solid was collected
5. customdried in vacuo