Trifluoroacetic acid → 4-tert-Butyl-3-(2-methoxyethoxy)phenol

Participants

Reaction Steps

To a methylene dichloride (3 ml) solution of tert-butyl 4-tert-butyl-3-(2-methoxyethoxy)phenyl carbonate (792 mg, 2.4 mmol) was added trifluoroacetic acid (TFA) (3 ml) and the mixture was stirred for 1 hour at ambient temperature. The solvent was removed under reduced pressure to give a residue, which was applied to a silica gel chromatography column and eluted with ethyl acetate/hexane=⅓ to furnish 0.32 g (59% yield) of the title compound as a white solid.

Provenance & Evidence